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238 Molecular dissection of tumor-immune microenvironment factors associated with response to checkpoint inhibitor therapy in non-small cell lung cancer patients using nanostring digital spatial profiling
Omar Jabado, Suzana Couto, Jordan Blum, Patrick Franken, Patricia Coutinho de Souza, Maria Jure-Kunkel, Nora Pencheva, Brandon Higgs, Kate Sasser, Mark Fereshteh

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A141-A142; DOI: 10.1136/jitc-2020-SITC2020.0238
27 The role of ligands of activatory receptor NKG2D in the immune-dependent pathogenesis and evolution of inflammatory bowel disease (IBD)
Heba Sidahmed, Shilpa Ravindran, Harshitha Manjunath, William Mifsud, Adrian Charles, Adham Ammar, Muhammad Khan, Saad Al-Kaabi, Anthony Akobeng, Muneera Al-Mohannadi, Mamoun Elawad, Sara Tomei, Cristina Maccalli

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A15; DOI: 10.1136/jitc-2020-SITC2020.0027
28 Retrospective pooled analysis of epacadostat clinical studies identifies doses required for maximal pharmacodynamic effect in anti-PD-1 combination studies
Michael Smith, Robert Newton, Sherry Owens, Xiaohua Gong, Chuan Tian, Janet Maleski, Lance Leopold

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A15-A16; DOI: 10.1136/jitc-2020-SITC2020.0028
251 Factors evaluated as predictors of exceptional response to PD-1 inhibitors in patients with head and neck squamous cell cancer
Alexander Song, Ron Ng, John Heller, Robin Petro, Ralph D’Agostino, Thomas Lycan, Mercedes Porosnicu

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A151; DOI: 10.1136/jitc-2020-SITC2020.0251
261 Association of T-cell–inflamed gene expression profile and PD-L1 status with efficacy of pembrolizumab in patients with esophageal cancer from KEYNOTE-180
Manish Shah, Takashi Kojima, Daniel Hochhauser, Peter Enzinger, Judith Raimbourg, Antoine Hollebecque, Florian Lordick, Sung-Bae Kim, Masahiro Tajika, Heung Tae Kim, A Craig Lockhart, Hendrick-Tobias Arkenau, Farid El-Hajbi, Per Pfeiffer, Pooja Bhagia, Z Alexander Cao, Jared Lunceford, Shailaja Suryawanshi, Mark Ayers, Matt Marton, Ken Kato

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A159-A160; DOI: 10.1136/jitc-2020-SITC2020.0261
29 Profiling tumor circulating cell-free DNA with an enhanced whole-exome to enable sensitive assessment of somatic mutations
Simo Zhang, Mengyao Tan, Fabio CP Navarro, Josette Northcott, Shuyuan Ma, Christopher Nelson, Devayani Bhave, L Gordon Bentley, Manju Chinnappa, Dan Norton, Gabor Bartha, Jason Harris, John Lyle, Sean Boyle, John West, Richard Chen

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A16; DOI: 10.1136/jitc-2020-SITC2020.0029
262 Tumoral DKK1 expression correlates with better clinical outcomes in patients with advanced esophagogastric cancer (EGC) treated with DKN-01
Samuel Klempner, Michael Kagey, Cynthia Sirard, Cynthia Sirard

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A160; DOI: 10.1136/jitc-2020-SITC2020.0262
263 Pleiotropic effects of IL-7 in prostate cancer patients receiving Sipuleucel-T vaccination
Caroline Duault, Nirasha Ramchurren, Russell Pachynski, Lawrence Fong, Sean Bendall, Mina Pichavant, Bita Sahaf, Chihiro Morishima, Leonard D’Amico, Martin Cheever, Steven Fling, Holden Maecker

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A160-A161; DOI: 10.1136/jitc-2020-SITC2020.0263
270 A phase II basket trial of dual anti-CTLA-4 and anti-PD-1 blockade in rare tumors (DART) SWOG S1609: the thyroid tumor cohort
Young Kwang Chae, Megan Othus, Sandip Patel, Sarah Fenton, Ding Wang, Cristina Rodriguez, Adedayo Onitilo, Ahmad Mattour, Igor Rybkin, Jourdain Hayward, Christine McLeod, Helen Chen, Elad Sharon, Edward Mayerson, Christopher Ryan, Melissa Plets, Charles Blanke, Razelle Kurzrock

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A161; DOI: 10.1136/jitc-2020-SITC2020.0270
264 Correlation of virus-specific CD8+ T cells to clinical response following treatment with Pexa-Vec and Cemiplimab in patients with advanced renal cell carcinoma
Myles Dillon, Lianjie Li, Jeongsook Bang, Nicholas Gaspar, Jessica Kuhnert, Nathalie Fiaschi, Vladimir Jankovic, Israel Lowy, Gavin Thurston, Glenn Kroog, Kyoung Soo Ha, Raquel Deering, Raquel Deering

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A161-A162; DOI: 10.1136/jitc-2020-SITC2020.0264

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