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221 Digital assessment of stromal B cell aggregates as a biomarker of response to immune checkpoint inhibition in unresectable melanoma
James W Smithy, Xiyu Peng, Andrea P Moy, Nathaniel Aleynick, Mingqiang Zhuang, Yanyun Li, Colleen Maher, Jasme Lee, Fiona Ehrich, Katherine S Panageas, Ronglai Shen, Travis Hollmann, Margaret K Callahan

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A252; DOI: 10.1136/jitc-2023-SITC2023.0221
222 The chick embryo chorioallantoic membrane (CAM) as a platform for assessing the in vivo efficacy of chimeric antigen receptor (CAR) T cell therapy in solid tumors
Allison Nipper, Emilie AK Warren, Gabrielle Wells, Caroline Porter, Mariana Villanueva, Hsuan-Chen Liu, Hugo Villanueva, Masataka Suzuki, Andrew Sikora

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A253; DOI: 10.1136/jitc-2023-SITC2023.0222
223 CAR-T cells expressing both IL-7 and CCL19 induce epitope spreading via cross presentation of endogenous tumor antigens
Keishi Adachi, Yukimi Sakoda, Koji Tamada

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A254; DOI: 10.1136/jitc-2023-SITC2023.0223
224 An inverse correlation of COL1A1 with CAR T cell treatment response in recurrent glioblastoma patients
Maryam Aftabizadeh, Sharareh Gholamin, Heine Natri, Jonathan Hibbard, Abbigael Aday, Sean Sepulveda, Eric Ma, Gaby Sanchez, Massimo D’Apuzzo, Nicholas Banovich, Behnam Badie, Christine Brown

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A255; DOI: 10.1136/jitc-2023-SITC2023.0224
225 Implantable biofactories for in vivo manufacture of CAR T cells
Pritha Agarwalla

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A256-A257; DOI: 10.1136/jitc-2023-SITC2023.0225
226 ‘Off-the-shelf’ CD19-CAR-T cells generated from umbilical cord blood display superior anti-tumor fitness and lower pro-inflammatory activity as compared to peripheral blood-derived engineered T cells
Asma Al Sulaiti, Mohammed El Anbari, Mohammed Toufiq, Shana Jacob, Saroja Kotegar Balayya, Salim Bougarn, Evonne Chin-Smith, Alex Issam Tout, Neha Gopinath, Damilola Olagunju, Chiara Cugno, Sara Deola, Suruchi Mohan, Damien Chaussabel, Chiara Bonini, Monica Casucci, Cristina Maccalli

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A258; DOI: 10.1136/jitc-2023-SITC2023.0226
227 Targeting TGFβ pathway to enhance CAR-T therapy for glioblastoma
Darya Alizadeh, Robyn Nee, Zhiqiang Wang, Madeleine Maker, Franklin Chen, Jonathan Hibbard, Christine Brown

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A259; DOI: 10.1136/jitc-2023-SITC2023.0227
228 Engineered human IL-2/IL-2Rß orthogonal pairs selectively enhance anti-GPC3 CAR T cells in vivo to drive complete responses in solid epithelial tumor models
Paul-Joseph Aspuria, Marie Semana, Ivan Cheng, Navneet Ratti, Mahalaksmi Ramadass, Deepti Rokkam, Mohammed Ali, Michele Bauer, Ryan Burgess, Henry Rosas, Sandro Vivona, George Zheng, Patrick Lupardus, Martin Oft

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A260; DOI: 10.1136/jitc-2023-SITC2023.0228
1 Nilogen Oncosystem’s 3D-EXpress platform allows rapid assessment of mono and combo targeted and immune therapies using a biorepository of fresh patient tumoroids with intact tumor microenvironment
Michelle Ataya, Seth Currlin, Angie Rivera, Jasmin D’Andrea, Alliyah Humphrey, Jared Ehrhart, Rikhia Chakraborty, Soner Altoik

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1; DOI: 10.1136/jitc-2023-SITC2023.0001
10 Enhancing the therapeutic responses of anti-human CCR8 mAbs utilizing the fully humanized CCR8 knockin mice
Yi Li, Hechun Ma, Lei Ci, Kaixia Lian, Demi X Liu, Jian Fei, Ruilin Sun, Daniel X He

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A10; DOI: 10.1136/jitc-2023-SITC2023.0010

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