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869 Venetoclax, a specific BCL-2 inhibitor, modulates CAR T cells genetically and functionally during production and augments their anti-tumor response
Nada S Aboelella, Ryan Park, Tony Pan, Erting Tang, Jun Huang, James LaBelle

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A968; DOI: 10.1136/jitc-2023-SITC2023.0869
870 CoREST inhibition by TNG260 increases expression of immunomodulatory genes in STK11-mutant cancer and sensitizes to immune checkpoint blockade
Leanne Ahronian, Minjie Zhang, Preksha Shahagadkar, Alborz Bejnood, Alice W Tsai, Chengyin Min, Lauren Flynn, Nikitha Das, Andre Mignault, Yi Yu, Heather DiBenedetto, Alan Huang, Adam S Crystal, Xinyuan Wu

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A969; DOI: 10.1136/jitc-2023-SITC2023.0870
871 Combining KRAS^G12C(ON) inhibitor with SHP2 and/or immune checkpoint blockade to overcome adaptive resistance and enhance anti-tumour immunity in lung cancer
Panayiotis Anastasiou, Christopher Moore, Sareena Rana, Jesse Boumelha, Mona Tomaschko, Miriam Molina-Arcas, Julian Downward

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A970; DOI: 10.1136/jitc-2023-SITC2023.0871
872 Combined multi-omics analysis delineates the impact of epigenetic therapies on the immunopeptidome of acute myeloid leukemia
Jens Bauer, Regina Bohnert, Elke Schaeffeler, Jonas Scheid, Marissa Dubbelaar, Annika Nelde, Marcel Wacker, Hans-Georg Rammensee, Matthias Schwab, Juliane S Walz

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A971; DOI: 10.1136/jitc-2023-SITC2023.0872
873 ISM5939, a novel, potent, orally available, selective ENPP1 inhibitor enhances the anti-tumor effects of immune checkpoint inhibitors in syngeneic murine cancer models
Celia Chen, Jin Liu, Jianyu Wu, Xin Cheng, Luoheng Qin, Supriya Bavadekar, Man Zhang, Sujata Rao, Feng Ren, Alex Zhavoronkov

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A972; DOI: 10.1136/jitc-2023-SITC2023.0873
874 A quantitative systems pharmacology model of head and neck squamous cell carcinoma: a tool for evaluating treatment outcomes for combination therapies
Alexandra Diakonova, Sergey Smirnov, Anna Roskoshnaia, Ivan Borisov, Oleg Demin, Gaurav Bajaj, Homer Adams, Maria Jure-Kunkel, Manish Gupta, Craig Thalhauser

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A973-A974; DOI: 10.1136/jitc-2023-SITC2023.0874
875 CA-4948 alters tumor associated macrophage activity in the tumor microenvironment of murine models of melanoma metastases
Bently Doonan, Christina Von Roemeling, Rylynn Russell, Amanda Acevedo, Savannah Carpenter, Nicholas Hincapie, Yousif Shakoury, Duane A Mitchell

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A975; DOI: 10.1136/jitc-2023-SITC2023.0875
876 Self-replicating RNA therapeutics for off-the-shelf precision immunotherapy targeting acquired resistance mutations in low TMB tumors
Zelanna Goldberg, Christian Maine, Gabrielle P Dailey, Christine Domingo, Gaelle Picarda, Hunter Little, Annie Chou, Jessica Sparks, Darina Spasova, Shigeki Miyake-Stoner, Christopher A Rabiola, Erika J Crosby, Zachary C Hartman, Herbert K Lyerly, Nathaniel Wang, Parinaz Aliahmad

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A976; DOI: 10.1136/jitc-2023-SITC2023.0876
877 Intermittent dosing of the ataxia telangiectasia and Rad3-related (ATR) inhibitor ceralasertib promotes antitumor immunity by remodelling the tumor immune microenvironment in pre-clinical models
Elizabeth Hardaker, Ankur Karmokar, Marta Milo, Chrysiis Michaloglou, Adina Hughes, Matthew King, Anisha Solanki, Lukasz Magiera, Ricardo Miragaia, Gozde Kar, Alison Peter, Sara Talbot, Carolyn Lam, Daniel Sutton, Scott Hoffmann, Larissa Carnevalli, Zena Wilson, Stephen Fawell, Mark Cobbold, Viia Valge-Archer, Dmitry Gabrilovich, Alan Lau, Simon Barry

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A977; DOI: 10.1136/jitc-2023-SITC2023.0877
878 T cell immunotherapies recruit and activate neutrophils to eliminate tumor antigen escape variants
Daniel Hirschhorn, Sadna Budhu, Lukas Kraehenbuehl, Mathieu Gigoux, David Schröder, Andrew Chow, Jacob M Ricca, Billel Gasmi, Olivier De Henau, Levi Mark B Mangarin, Yanyun Li, Anne-Laure Flamar, Heyjin Choi, Czrina A Cortez, Cailian Liu, Aliya Holland, Sara Schad, Isabell Schulze, Linda Hamadene, Allison Betof Warner, Travis Hollmann, Arshi Arora, Katherine S Panageas, Rebekka Duhen, Andrew D Weinberg, Gabrielle A Rizzuto, Christine N Spencer, David Ng, Xue-Yan He, Jean Albrengues, David Redmond, Mikala Egeblad, Jedd D Wolchok, Taha Merghoub

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A978; DOI: 10.1136/jitc-2023-SITC2023.0878

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