Open access

1407 Expanding the therapeutic index of MMAE-based antibody-drug conjugates (ADCs) with a novel linker system (LD343)
Haidong Liu, Yang Xiao, Guobao Wang, Wanwan Shen, Lei Wang, Xiao Shang, Baiteng Zhao, Zhu Chen

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1565; DOI: 10.1136/jitc-2023-SITC2023.1407
1408 Non-canonical peptide sources broaden the landscape of targetable antigens in pancreatic cancer
Zackery A Ely, Zachary J Kulstad, Jennifer G Abelin, Eva K Verzani, Sudarsana Addepalli, Karl Clauser, Kevin S Kapner, Connor J Hennessey, Miles Agus, Susan Klaeger, Alex M Jaeger, Jennifer Su, Philip D Greenberg, Andrew J Aguirre, Steven Carr, Tyler Jacks, William Freed-Pastor

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1566; DOI: 10.1136/jitc-2023-SITC2023.1408
1409 Autoimmune disease and immunosuppressive therapy in relapsed long-term breast cancer survivors treated with cyclin-dependent kinase inhibitors and human epidermal receptor-2 monoclonal antibodies
Jose Juan Illarramendi, Esteban Salgado, Susana De La Cruz, Jorge Illarramendi Esteban, Juan Ignacio Arraras, Gemma Asin, Ana Manterola

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1567; DOI: 10.1136/jitc-2023-SITC2023.1409
1410 Uncovering therapeutic vulnerabilities in gastric cancer with patient-specific microphysiological tumor spheroid systems
Jihoon Ko, Sujin Hyung, Young Sun Oh, Noo Li Jeon, Jeeyun Lee

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1568; DOI: 10.1136/jitc-2023-SITC2023.1410
1411 Feasibility, safety, and efficacy of personal vaccines consisting of autologous dendritic cells loaded ex vivo with autologous tumor antigens from self-renewing cancer cells
Robert O Dillman, Gabriel I Nistor, Hans S Keirstead

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1569; DOI: 10.1136/jitc-2023-SITC2023.1411
1412 STING agonist loaded lipid nanoparticle and CpG-ODN induces CD11bhigh CD27low memory-like NK cells that prevent melanoma lung metastasis
Alaa Khalifa, Takashi Nakamura, Yusuke Sato, Hideyoshi Harashima

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1570; DOI: 10.1136/jitc-2023-SITC2023.1412
1413 Immunogenicity of SARS-CoV-2 mRNA vaccines in individuals with thymic epithelial tumors
Madison Ballman, Hanna S Loving, Shannon Swift, Meredith McAdams, Chen Zhao, Eva Szabo, Hyoyoung Choo-Wosoba, Seth M Steinberg, James L Gulley, Renee N Donahue, Jeffrey Schlom, Roa Harb, Arun Rajan

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1571; DOI: 10.1136/jitc-2023-SITC2023.1413
1414 Antitumor effect of HER2-hICD vaccine combining with HER2 ADC depending on T cell existence in a mouse model: pooled analysis
JinHo Kang, Hyo-Hyun Park, Jee Hyun Choi, Jinback Lim, Hye-Ran Kim, Seong-Yong Jang, Min-Ah Kim, Myeong-Kyu Park, Yun-Hee Park, Soyeon Lim, Chul-Woong Chung, Jin Kyeong Choi, Eunkyo Joung, Hun Jung

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1572; DOI: 10.1136/jitc-2023-SITC2023.1414
1415 Thoracic FLASH radiotherapy significantly spares peripheral blood lymphocytes and improves proliferation of bone marrow stem/progenitor cells and lymphopenia recovery
Rong-Hua Tao, Kevin Liu, Denae Neill, Brett Velasquez, Nefetiti Mims, Emil Schüler, Steven H Lin

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1573; DOI: 10.1136/jitc-2023-SITC2023.1415
1416 Common metabolic adaptations empower CD8 T cell tissue residency and antitumor immunity
Miguel Reina Campos, Maximilian Heeg, Kelly Kennewick, Ian Mathews, Giovanni Galletti, Vida Luna, Quynhanh Nguyen, Hongling Huang, Justin Milner, Kenneth Hu, Amy Vichaidit, Natalie Santillano, Brigid Boland, John T Chang, Mohit Jain, Sonia Sharma, Max Krummel, Hongbo Chi, Steven Bensinger, Ananda Goldrath

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1574; DOI: 10.1136/jitc-2023-SITC2023.1416

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