Open access

1498 Deploying spatial transcriptomics to inform on intratumoral heterogeneity in late-stage uveal melanoma leveraging advanced preclinical modeling and clinical samples
Sanjana Srinivasan, Johnathon Rose, Joseph R Daniele, Michael Peoples, Meng He, Rosalba Minelli, Christopher Terranova, Chiu-Yi Liu, Jason Gay, Melinda Soeung, Khalida Wani, Luigi Perelli, Dmitry Loza, Ningping Feng, Christopher P Vellano, Joseph Marszalek, Giulio F Draetta, Phillip Andrew Futreal, Scott Woodman, Alexander J Lazar, Timothy Heffernan, Alessandro Carugo, Giannicola Genovese, Virginia Giuliani

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1662; DOI: 10.1136/jitc-2023-SITC2023.1498
1499 Molecular and immune profiling of lobular-enriched versus non-lobular invasive breast cancers
Kyle C Strickland, Sarabjot Pabla, Heidi Ko, Rebecca A Previs, Zachary D Wallen, Mary K Nesline, Shengle Zhang, Jeffrey M Conroy, Jennifer B Jackson, Kamal S Saini, Taylor J Jensen, Brian Caveney, Marcia Eisenberg, Prasanth Reddy, Eric A Severson, Shakti Ramkissoon

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1663; DOI: 10.1136/jitc-2023-SITC2023.1499
1500 Integrated immunogenomic and digital histopathological analysis reveals correlation of immune landscape with the molecular subtypes in leiomyosarcoma
Aditya Suru, Alexandre Maalouf, Lingling Chen, Ada Tam, William Villasi, Lindy Zhang, Meytal Guller, Shivang Sharma, Christian Meyer, Jonathan Greer, Fabian Johnston, Carol Morris, Sophia A Strike, Adam Levin, Daniel Rhee, Brian Ladle, Kornel Schuebel, Yan Zhang, Rulin Wang, Srinivasan Yegnasubramanian, John Gross, Robert Anders, Drew Pardoll, Nicolas Llosa

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1664; DOI: 10.1136/jitc-2023-SITC2023.1500
1501 Evidence of immune suppression in PBMC of patients newly diagnosed with ductal carcinoma in situ (DCIS)
Sedigheh Taghinezhadsaroukalaei, Amirhossein Mohseni, Pamela Beatty, Olivera J Finn

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1665; DOI: 10.1136/jitc-2023-SITC2023.1501
1502 Tumor heterogeneity impedes immunotherapy through driving spatially organized pockets of immunosuppression
Miho Tanaka, Lotus Lum, Kenneth Hu, Cecilia Ledezma-Soto, Bushra Samad, Daphne Superville, Kenneth Ng, Zoe Adams, Kelly Kersten, Lawrence Fong, Alexis Combes, Max Krummel, Melissa Q Reeves

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1666; DOI: 10.1136/jitc-2023-SITC2023.1502
1503 Optimization of an Integrated MultiOmyx-RNAscope hyperplex assay for co-detection and characterization of multiple protein and RNA biomarkers within the tumor microenvironment (TME)
Courtney Todorov, Sandra Lam, Harry Nunns, Kevin Gallagher, Juliana Wortman, Elaine Yeung, Eric Leones, Flora Shafi, Erinn Parnell, Qingyan Au

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1667; DOI: 10.1136/jitc-2023-SITC2023.1503
1504 Epithelial to mesenchymal transition (EMT) can be driven by macrophages through multiple signalling pathways
Darryl Turner, Ross Dobie, Justyna Rzepecka, Hayley Gooding, Matilda Bingham

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1668; DOI: 10.1136/jitc-2023-SITC2023.1504
1505 Spatial profiling of the SCLC tumor microenvironment defined by high MHC-I expression reveals association with functionally relevant antigen presentation
Miljenka Vuko, Felix Segerer, Mingchao Xie, Monica Azqueta Gavaldon, Andreas Spitzmüller, Harald Hessel, Alma Andoni, Marco Testori, Michael Surace, Mari Heininen-Brown, Jaime Rodriguez Canales, Shashank Saran, Helen Angell, Guenter Schmidt, Nicolas Brieu, Hadassah Sade, J Carl Barrett, Markus Schick, Giulia Fabbri

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1669; DOI: 10.1136/jitc-2023-SITC2023.1505
1507 The Galectin-9-Tim-3 pathway is a novel checkpoint target for patients with biliary tract cancer
Emilie AK Warren, Jacklyn Hammons, Jessica Keilson, Guillermo O Rangel-Rivera, Megan M Wyatt, Caroline R Goel, Curtis J Henry, Sarah Kulkarni, Yuan Liu, Brian Robinson, Alyssa Krasinskas, Shishir Maithel, Chrystal M Paulos, Gregory B Lesinski

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1672; DOI: 10.1136/jitc-2023-SITC2023.1507
1508 Analyzing the genomic, transcriptomic and immune landscapes associated with surface somatostatin receptor 2 (SSTR2) gene expression in nasopharyngeal carcinoma (NPC)
Dara Bracken-Clarke, Harris Krause, Nishant Gandhi, Phillip Walker, Minh Phan, Rusha Patel, Heloisa Soares, Emil Lou, Ari VanderWalde, James L Gulley, Charalampos S Floudas

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1673; DOI: 10.1136/jitc-2023-SITC2023.1508

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