Open access

674 Late antibiotic administration during durvalumab treatment may be associated with clinical benefit
Siddharth Sheth, Christopher Morehouse, Elizabeth Dozier, Chen Gao, Paul Warrener, Vancheswaran Gopalakrishnan, Scott Hammond, Taylor Cohen, Bret Sellman

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A404-A405; DOI: 10.1136/jitc-2020-SITC2020.0674
673 Precision microbiome mapping identifies a microbiome signature predictive of Immune checkpoint inhibitor response across multiple research study cohorts
Matthew Robinson, Kevin Vervier, Simon Harris, David Adams, Doreen Milne, Catherine Booth, Emily Barker, Christine Parkinson, David Bruce, Sarah Welesh, Pippa Corrie, Trevor Lawley

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A404; DOI: 10.1136/jitc-2020-SITC2020.0673
676 PD-L1 is induced by the periodontal pathogen porphyromonas gingivalis and can be blocked by small molecule gingipain inhibitors, including atuzaginstat
Shirin Arastu-Kapur, Mai Nguyen, Sean Broce, Joseph Vacca, Kirk Ehmsen, Florian Ermini, Ursula Haditsch, Aurora Martinez-Horta, Debasish Raha, Leonardo Rodriguez, Casey Lynch, Stephen Dominy, Leslie Holsinger

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A406-A407; DOI: 10.1136/jitc-2020-SITC2020.0676
678 Addition of a single bacteria facilitates anti-tumor immunity and long-term survival in colorectal cancer
Abigail Overacre-Delgoffe, Anthony Cillo, Hannah Bumgarner, Ansen Burr, Justin Tometich, Amrita Bhattacharjee, Tullia Bruno, Dario Vignali, Timothy Hand

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A407-A408; DOI: 10.1136/jitc-2020-SITC2020.0678
677 Evaluation of anti-PD1 efficacy in germ-free and antibiotic-treated SPF mice bearing MC38 tumors
Ying Jin, Xue Liang, Frieda Zhang, Guangmao Mu, Wei Zhou, Annie An, Marvin Ouyang, Cai Li, Andy Liaw, Henry Li, Davy Ouyang

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A407; DOI: 10.1136/jitc-2020-SITC2020.0677
680 Automated Ion torrent based solution enables accurate gut microbiome quantification of bacterial species relevant to research in cancer and its response to immunotherapy
Shrutii Sarda, David Merrill, Heesun Shin, Anna McGeachy, Birgit Drews, Wing Lee, Rajesh Gottimukkala, Janice Au-Young, Fiona Hyland

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A408-A409; DOI: 10.1136/jitc-2020-SITC2020.0680
681 Single pipeline re-analysis revises microbiome associations with anti-tumor response to checkpoint inhibitors
Fyza Shaikh, James White, Joell Gills, Taiki Hakozaki, Richard Corentin, Bertrand Routy, Yusuke Okuma, Mykhaylo Usyk, Abhishek Pandey, Jeffrey Weber, Jiyoung Ahn, Jarushka Naidoo, Evan Lipson, Drew Pardoll, Cynthia Sears

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A409; DOI: 10.1136/jitc-2020-SITC2020.0681
68 The prognostic and predictive implications of the 12-chemokine score in muslce invasive bladder cancer
Roger Li, Logan Zemp, Anders Berglund, Jasreman Dhillon, Ryan Putney, Youngchul Kim, Rohit Jain, Daniel Grass, Jingsong Zhang, Michael Poch, Julio Pow-Sang, Wade Sexton, Scott Gilbert, Shari Pilon-Thomas, José Conejo-Garcia, Colin Dinney, James Mulé

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A41-A42; DOI: 10.1136/jitc-2020-SITC2020.0068
683 A novel mechanism of neuropilin-1 inhibition results in improved tumor growth inhibition in vivo
Eric Zhu, Daniel Blom, Shalini Sethumadhavan, Chengfeng Merriman, Katherine Molloy, Alexandria Fink, Shan Lou, Andrew Rogantino, Ameya Apte, Mandana abbassi, Tiffany Liao, Hongyue Dai, Aaron Fulgham, Jonathan Hurov, Pearl Huang

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A410; DOI: 10.1136/jitc-2020-SITC2020.0683
685 A highly selective and potent HPK1 inhibitor enhances immune cell activation and induces robust tumor growth inhibition in a murine syngeneic tumor model
David Ciccone, Vad Lazari, Ian Linney, Michael Briggs, Samantha Carreiro, Joshua McElwee, Ian Waddell, Chris Hill, Christine Loh, Peter Tummino, Alan Collis, Neelu Kaila

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A411; DOI: 10.1136/jitc-2020-SITC2020.0685

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