Open access

292 Immune checkpoint inhibitor induced overlapping cardiac and neuromuscular toxicities: Highlight of early diagnosis, early initiation of immunosuppressive therapy and multidisciplinary management
Ho Wai Siu, Robert O’Neill, Matthew Tong, JunHee Hong, Carole A Harris, Morteza Aghmesheh, Hussein Soudy

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A178-A179; DOI: 10.1136/jitc-2020-SITC2020.0292
294 CD8 PET imaging of tumor infiltrating T cells in advanced solid tumors: a phase I first-in-human study of 89Zr-IAB22M2C, a radiolabeled anti-CD8 minibody
Michael Farwell, Raymond Gamache, Neeta Pandit-Taskar, Mike Postow, Michael Gordon, Ian Wilson, Alessandro Mascioni, Anna Wu, William Le, Avital Weiss, Ronald Korn

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A179-A180; DOI: 10.1136/jitc-2020-SITC2020.0294
33 Dynamic monitoring of response to immune checkpoint blockade through deep-learning empowered ultra-sensitive liquid biopsy in melanoma
Adam Widman, Cole Khamnei, Jake Bass, Will Liao, Minita Shah, Nicolas Robine, Jedd Wolchok, Margaret Callahan, Dan Landau

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A18-A20; DOI: 10.1136/jitc-2020-SITC2020.0033
297 Modeling the efficacy of NY-ESO-1 TCR T cells (letetresgene autoleucel; GSK3377794) in patients with synovial sarcoma: correlations of response with transduced cell kinetics and biomarkers
Alexandra Gyurdieva, Stefan Zajic, Ya-Fang Chang, E Andres Houseman, Shan Zhong, Jaegil Kim, David Turner, Laura Johnson, Ioanna Eleftheriadou, Jenna Tress, Aisha Hasan, Victoria Chiou, Naimish Pandya, John Glod, Dejka Araujo, Warren Chow, Mihaela Druta, George Demetri, Brian Van Tine, Sandra D’Angelo

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A181-A182; DOI: 10.1136/jitc-2020-SITC2020.0297
169 Microfluidics cell squeezing enables human PBMCs as drivers of antigen-specific CD8 T responses across broad range of antigens for diverse clinical applications
Michael Maloney, Scott Loughhead, Amritha Ramakrishnan, Carolyne Smith, Anita Venkitaraman, Christian Yee, Miye Jacques, Defne Yarar, Armon Sharei, Howard Bernstein, Kelan Hlavaty, Melissa Myint, Katherine Seidl

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A183; DOI: 10.1136/jitc-2020-SITC2020.0169
303 Phase II trial of neoadjuvant nivolumab (Nivo) and intra-tumoral (IT) CMP-001 in high-risk resectable melanoma (Neo-C-Nivo): final results
Diwakar Davar, Arivarasan Karunamurthy, Douglas Hartman, Richelle DeBlasio, Joe-Marc Chauvin, Quanquan Ding, Ornella Pagliano, Amy Rose, John Kirkwood, Hassane Zarour

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A185-A186; DOI: 10.1136/jitc-2020-SITC2020.0303
302 A phase I trial of intratumoral PVSRIPO in patients with unresectable treatment refractory melanoma
Georgia Beasley, Nellie Farrow, Karenia Landa, Maria Angelica Seilm, Sin-Ho Jung, Darell Bigner, Andrea True Kelly, Smita Nair, Matthias Gromeier, April Salama

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A185; DOI: 10.1136/jitc-2020-SITC2020.0302
305 Technical considerations for normalizing digital spatial profiling data with multiple within-patient samples
Tyler Hether, Tim Howes, Christine Spencer, Travis Hollman, Jason Reeves, Danny Wells, Claire Friedman, Theresa LaVallee, Jedd Wolchok, Sarah Warren

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A187; DOI: 10.1136/jitc-2020-SITC2020.0305
309 The role of tumor-draining lymph nodes in the tuning of systemic T cell immunity by CTLA-4 blockade is revealed by local delivery of tremelimumab in early-stage melanoma: data from a Phase-I trial
Jessica Notohardjo, Kim van Pul, Anita Stam, Dafni Chondronasiou, Sinead Lougheed, Petrousjka van den Tol, Karin Jooss, Ronald Vuylsteke, Alfons van den Eertwegh, Tanja de Gruijl

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A190; DOI: 10.1136/jitc-2020-SITC2020.0309
311 Phase II trial of lymphodepletion plus adoptive cell transfer with or without dendritic cell vaccination in patients with metastatic melanoma
Chantal Saberian, Rodabe Amaria, Cara Haymaker, Marie Andree Forget, Roland Bassett, Isabella Glitza, Gregory Lizee, Cassian Yee, Jeniffer McQuade, Michael Wong, Hussein Tawbi, Sapna Patel, Adi Diab, Michael Davies, Patrick Hwu, Chantale Bernatchez

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A191-A192; DOI: 10.1136/jitc-2020-SITC2020.0311

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