Open access

13 Use of anti-viral T cells to model HLA-restricted anti-tumor cytotoxic lymphocyte responses
Michael Overstreet, Vanessa Muniz-Medina, Ruoyan Chen, James Kurasawa, Stacy Kentner, Deepali Malhotra, Jane Osbourn, Jill Walker, Gordon Moody

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A7; DOI: 10.1136/jitc-2020-SITC2020.0013
116 Multi-antigen targeting of heterogenous solid tumors using CAR T cells secreting bi-specific T-cell engagers
Martin Hosking, Bishwas Shrestha, Megan Boyett, Soheila Shirinbak, Angela Gentile, Eric Sung, Yijia Pan, Tom Lee, Jason ORourke, Dan Shoemaker, Cokey Nguyen, Bahram Valamehr

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A71-A72; DOI: 10.1136/jitc-2020-SITC2020.0116
66 Complex markers of survival from pembrolizumab: the potential predictive role of tumor mutational burden (TMB) and KRAS
Yong Hee Lee, Carrie Hoefer, Paul DePietro, Mary Nesline

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A71; DOI: 10.1136/jitc-2020-SITC2020.0066
124 Optimizing the generation from umbilical cord blood of ‘off-the-shelf’ CD19-chimeric antigen receptor (CAR) expressing T cells
Cristina Maccalli, Asma Al Sulaiti, Moza Al Khulaifi, Shilpa Ravindran, Mohammed El-Anbari, Mohammed Toufiq, Rebecca Mathew, Chiara Bonini, Monica Casucci, Chiara Cugno, Suruchi Mohan, Sara Deola, Damien Chaussabel, Sara Tomei

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A75-A76; DOI: 10.1136/jitc-2020-SITC2020.0124
15 A novel CD28 humanized mouse model for efficacy assessment of CD28-targeting therapies
Fabiane Sônego, Gaelle Martin, Chloé Beuraud, Audrey Beringer, Yacine Cherifi, Alexandre Fraichard, Patricia Isnard-Petit, Kader Thiam

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A8; DOI: 10.1136/jitc-2020-SITC2020.0015
132 CAR macrophages (CAR-M) elicit a systemic anti-tumor immune response and synergize with PD1 blockade in immunocompetent mouse models of HER2+ solid tumors
Stefano Pierini, Rashid Gabbasov, Linara Gabitova, Yumi Ohtani, Michael Klichinsky

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A80-A81; DOI: 10.1136/jitc-2020-SITC2020.0132
761 Potential predictive biomarkers of rapid progression and response to anti-PD1 treatment by gene profiling analysis in metastatic melanoma patients
Maria Grazia Vitale, Domenico Mallardo, Antonio Grimaldi, Ncholas Bayless, Mariaelena Capone, Gabriele Madonna, Vito Vanella, Lucia Festino, Claudia Trojaniello, Marcello Curvietto, Luigi Scarpato, Sarah Warren, SuFey Ong, Ernesta Cavalcanti, Corrado Caracò, Alessandra Cesaro, Ester Simeone, Paolo Ascierto

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A809; DOI: 10.1136/jitc-2020-SITC2020.0761
134 Tumor-responsive, multi-functional genetically-engineered natural killer cells for immunotherapy of glioblastoma
Jiao Wang, Yeonhee Yun, Karen E Pollok, Anthony L Sinn, Randy R Brutkiewicz, Michael C Veronesi, Sandro Matosevic, Jiao Wang

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A81-A82; DOI: 10.1136/jitc-2020-SITC2020.0134
168 A novel prostate-restricted tumor-associated antigen: a potential therapeutic target
Zoila (Areli) Lopez Bujanda, Aleksandar Obradovic, Thomas Nirschl, Timothy O’Donnell, Uri Laserson, Rodney Macedo-Gonzales, Ran Reshef, Tiezheng Yuan, Mithil Soni, Emmanuel Antonarakis, Benjamin Larman, Pawel Muranski, Charles Drake, Zoila (Areli) Lopez Bujanda

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A101; DOI: 10.1136/jitc-2020-SITC2020.0168
171 Preclinical studies support therapeutic application of the leukemic cell-based cancer relapse vaccine DCP-001 in ovarian cancer
Maho Nagasawa, Remco Bos, Haoxiao Zuo, Kiave Yune Ho Wang Yin, Marie-José van Lierop, Sebastien Tabruyn, Erik Manting, Marco de Bruyn, Hans Nijman, Satwinder KAur Singh, Satwinder Kaur Singh

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A102-A103; DOI: 10.1136/jitc-2020-SITC2020.0171

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