Open access

492 Integration of high dimensional datasets in an immunocompetent mammary mouse model reveals pathways of tolerance and resistance to immune checkpoint blockade
Lin Ma, Jian-Hua Mao, Mary Helen Barcellos-Hoff, Jade Moore

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A304; DOI: 10.1136/jitc-2020-SITC2020.0492
500 P2RX7 agonist treatment boosts the ability of IL-12-activated CD8+ T cells to infiltrate and control murine melanoma
Kelsey Wanhainen, Stephen Jameson, Henrique Borges Da Silva

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A307-A308; DOI: 10.1136/jitc-2020-SITC2020.0500
503 Tumor infiltrating lymphocytes in soft tissue sarcomas upregulate the exhaustion marker TIGIT and are reinvigorated by IL-15 stimulation and TIGIT blockade
Sean Judge, Morgan Darrow, Steven Thorpe, Alicia Gingrich, Edmond O’Donnell, Alyssa Bellini, Ian Sturgill, Logan Vick, Cordelia Dunai, Kevin Stoffel, Yue Lyu, Shuai Chen, May Cho, Robert Rebhun, Arta Monjazeb, William Murphy, Robert Canter

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A309; DOI: 10.1136/jitc-2020-SITC2020.0503
505 Activation of NK T cells promote the inflammatory tumor microenvironment and control the growth of solid tumor
Sourav Paul, Amrita Mishra, Sushanta Chhatar, Girdhari Lal, Girdhari Lal

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A310; DOI: 10.1136/jitc-2020-SITC2020.0505
504 Using multiplexed immunofluorescence to quantitatively analyze myeloid derived suppressor cells (MDSCs) in relation to tertiary lymphoid structures (TLS) in bladder cancer
Anna Juncker-Jensen, Gang Huang, Mate Nagy, Xin Lu

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A310; DOI: 10.1136/jitc-2020-SITC2020.0504
506 The tumor immune microenvironment of metastatic osteosarcoma is marked by lymphocyte exclusion and impacts patient progression-free survival
John Ligon, Woonyoung Choi, Gady Cojocaru, Wei Fu, Emily Hsiue, Teniola Oke, Carol Morris, Adam Levin, Daniel Rhee, David McConkey, Robert Anders, Drew Pardoll, Nicolas Llosa

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A310-A312; DOI: 10.1136/jitc-2020-SITC2020.0506
511 Tumor immune microenvironment in adult mice asynchronously cross-fostered as pups
Vianca Vianzon, Ishita Garg, Kara Greenfield, Kathryn Knoop, Laura Rogers

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A314-A315; DOI: 10.1136/jitc-2020-SITC2020.0511
513 CD26 enzymatic activity modulates efficient migration of adoptively transferred T cells to solid tumors
Megan Wyatt, Stefanie Bailey, Michelle Nelson, Hannah Knochelmann, Aubrey Smith, Guillermo Rangel RIvera, Amalia Rivera Reyes, Chrystal Paulos

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A315-A316; DOI: 10.1136/jitc-2020-SITC2020.0513
512 Terminally exhausted CD8+ T cells potentiate the tolerogenic tumor microenvironment as functional suppressors
Paolo Vignali, Kristin DePeaux, McLane Watson, Ashley Menk, Nicole Scharping, Greg Delgoffe

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A315; DOI: 10.1136/jitc-2020-SITC2020.0512
514 Disturbed Mitochondrial Dynamics Rewire the Epigenetic Program for CD8+ TIL Exhaustion
Yi-Ru Yu, Haiping Wang, Fabien Franco, Ping-Chih Ho

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A316; DOI: 10.1136/jitc-2020-SITC2020.0514

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