Open access

MYC oncogene is associated with suppression of tumor immunity and targeting Myc induces tumor cell immunogenicity for therapeutic whole cell vaccination
Xiaofang Wu, Marie Nelson, Mousumi Basu, Priya Srinivasan, Christopher Lazarski, Peng Zhang, Pan Zheng, Anthony David Sandler

Journal for ImmunoTherapy of Cancer Mar 2021, 9 (3) e001388; DOI: 10.1136/jitc-2020-001388
Complete metabolic response in patients with advanced non-small cell lung cancer with prolonged response to immune checkpoint inhibitor therapy
Justin Ferdinandus, Martin Metzenmacher, Lukas Kessler, Lale Umutlu, Clemens Aigner, Karl-Otto Kambartel, Viktor Grünwald, Wilfried Ernst Erich Eberhardt, Wolfgang Peter Fendler, Ken Herrmann, Martin Faehling, Daniel Christian Christoph

Journal for ImmunoTherapy of Cancer Mar 2021, 9 (3) e002262; DOI: 10.1136/jitc-2020-002262
Safety and activity of the TGFβ receptor I kinase inhibitor galunisertib plus the anti-PD-L1 antibody durvalumab in metastatic pancreatic cancer
Davide Melisi, Do-Youn Oh, Antoine Hollebecque, Emiliano Calvo, Anna Varghese, Erkut Borazanci, Teresa Macarulla, Valeria Merz, Camilla Zecchetto, Yumin Zhao, Ivelina Gueorguieva, Michael Man, Leena Gandhi, Shawn T Estrem, Karim A Benhadji, Mark C Lanasa, Emin Avsar, Susan C Guba, Rocio Garcia-Carbonero

Journal for ImmunoTherapy of Cancer Mar 2021, 9 (3) e002068; DOI: 10.1136/jitc-2020-002068
Fast progression in non–small cell lung cancer: results from the randomized phase III OAK study evaluating second-line atezolizumab versus docetaxel
David Gandara, Martin Reck, Denis Moro-Sibilot, Julien Mazieres, Shirish Gadgeel, Stefanie Morris, Andres Cardona, Diana Mendus, Marcus Ballinger, Achim Rittmeyer, Solange Peters

Journal for ImmunoTherapy of Cancer Mar 2021, 9 (3) e001882; DOI: 10.1136/jitc-2020-001882
Pre-existing effector T-cell levels and augmented myeloid cell composition denote response to CDK4/6 inhibitor palbociclib and pembrolizumab in hormone receptor-positive metastatic breast cancer
Colt Egelston, Weihua Guo, Susan Yost, Jin Sun Lee, David Rose, Christian Avalos, Jian Ye, Paul Frankel, Daniel Schmolze, James Waisman, Peter Lee, Yuan Yuan

Journal for ImmunoTherapy of Cancer Mar 2021, 9 (3) e002084; DOI: 10.1136/jitc-2020-002084
Complement C3a and C5a receptor blockade modulates regulatory T cell conversion in head and neck cancer
Jacob Gadwa, Thomas E Bickett, Laurel B Darragh, Michael William Knitz, Shilpa Bhatia, Miles Piper, Benjamin Van Court, Shiv Bhuvane, Diemmy Nguyen, Varuna Nangia, Emily K Kleczko, Raphael A Nemenoff, Sana D Karam

Journal for ImmunoTherapy of Cancer Mar 2021, 9 (3) e002585; DOI: 10.1136/jitc-2021-002585
Neoadjuvant chemoradiation alters biomarkers of anticancer immunotherapy responses in locally advanced rectal cancer
Incheol Seo, Hye Won Lee, Sang Jun Byun, Jee Young Park, Hyeonji Min, Sung Hwan Lee, Ju-Seog Lee, Shin Kim, Sung Uk Bae

Journal for ImmunoTherapy of Cancer Mar 2021, 9 (3) e001610; DOI: 10.1136/jitc-2020-001610
Severity of COVID-19 in patients with lung cancer: evidence and challenges
Antonio Passaro, Christine Bestvina, Maria Velez Velez, Marina Chiara Garassino, Edward Garon, Solange Peters

Journal for ImmunoTherapy of Cancer Mar 2021, 9 (3) e002266; DOI: 10.1136/jitc-2020-002266
Tumor-infiltrating plasmacytoid dendritic cells are associated with survival in human colon cancer
Maximilian Kießler, Ioana Plesca, Ulrich Sommer, Rebekka Wehner, Friederike Wilczkowski, Luise Müller, Antje Tunger, Xixi Lai, Anke Rentsch, Kenneth Peuker, Sebastian Zeissig, Adrian M Seifert, Lena Seifert, Jürgen Weitz, Michael Bachmann, Martin Bornhäuser, Daniela Aust, Gustavo Baretton, Marc Schmitz

Journal for ImmunoTherapy of Cancer Mar 2021, 9 (3) e001813; DOI: 10.1136/jitc-2020-001813
N-cadherin inhibitor creates a microenvironment that protect TILs from immune checkpoints and Treg cells
Yi Sun, Jun Jing, Huan Xu, Lingfan Xu, Hailiang Hu, Cai Tang, Shengzhuo Liu, Qiang Wei, Ruiqi Duan, Ju Guo, Lu Yang

Journal for ImmunoTherapy of Cancer Mar 2021, 9 (3) e002138; DOI: 10.1136/jitc-2020-002138

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