Open access

Checkpoint blockade accelerates a novel switch from an NKT-driven TNFα response toward a T cell driven IFN-γ response within the tumor microenvironment
Shota Aoyama, Ryosuke Nakagawa, Satoshi Nemoto, Patricio Perez-Villarroel, James J Mulé, Adam William Mailloux

Journal for ImmunoTherapy of Cancer Jun 2021, 9 (6) e002269; DOI: 10.1136/jitc-2020-002269
Immune checkpoint inhibitor treatment and atherosclerotic cardiovascular disease: an emerging clinical problem
Kikkie Poels, Suzanne I.M. Neppelenbroek, Marie José Kersten, M. Louisa Antoni, Esther Lutgens, Tom T.P. Seijkens

Journal for ImmunoTherapy of Cancer Jun 2021, 9 (6) e002916; DOI: 10.1136/jitc-2021-002916
Evaluation of tumor immune contexture among intrinsic molecular subtypes helps to predict outcome in early breast cancer
Quentin Klopfenstein, Valentin Derangère, Laurent Arnould, Marion Thibaudin, Emeric Limagne, Francois Ghiringhelli, Caroline Truntzer, Sylvain Ladoire

Journal for ImmunoTherapy of Cancer Jun 2021, 9 (6) e002036; DOI: 10.1136/jitc-2020-002036
Mesoporous silica nanoparticles inflame tumors to overcome anti-PD-1 resistance through TLR4-NFκB axis
Mayu Sun, Pengfei Gu, Yang Yang, Luodan Yu, Zheshun Jiang, Jingquan Li, Yingying Le, Yu Chen, Qian Ba, Hui Wang

Journal for ImmunoTherapy of Cancer Jun 2021, 9 (6) e002508; DOI: 10.1136/jitc-2021-002508
Massive PD-L1 and CD8 double positive TILs characterize an immunosuppressive microenvironment with high mutational burden in lung cancer
Libin Zhang, Yanhui Chen, Han Wang, Zheyuan Xu, Yang Wang, Sixing Li, Jun Liu, Yun Chen, Hongli Luo, Lijia Wu, Ying Yang, Henghui Zhang, Hao Peng

Journal for ImmunoTherapy of Cancer Jun 2021, 9 (6) e002356; DOI: 10.1136/jitc-2021-002356
Intracerebral administration of CTLA-4 and PD-1 immune checkpoint blocking monoclonal antibodies in patients with recurrent glioblastoma: a phase I clinical trial
Johnny Duerinck, Julia Katharina Schwarze, Gil Awada, Jens Tijtgat, Freya Vaeyens, Cleo Bertels, Wietse Geens, Samuel Klein, Laura Seynaeve, Louise Cras, Nicky D’Haene, Alex Michotte, Ben Caljon, Isabelle Salmon, Michaël Bruneau, Mark Kockx, Sonia Van Dooren, Anne-Marie Vanbinst, Hendrik Everaert, Ramses Forsyth, Bart Neyns

Journal for ImmunoTherapy of Cancer Jun 2021, 9 (6) e002296; DOI: 10.1136/jitc-2020-002296
Neoadjuvant immunotherapy for non-small cell lung cancer: right drugs, right patient, right time?
Elizabeth Ahern, Ben J Solomon, Rina Hui, Nick Pavlakis, Ken O'Byrne, Brett G M Hughes

Journal for ImmunoTherapy of Cancer Jun 2021, 9 (6) e002248; DOI: 10.1136/jitc-2020-002248
Phase II clinical trial using anti-CD3 × anti-HER2 bispecific antibody armed activated T cells (HER2 BATs) consolidation therapy for HER2 negative (0–2+) metastatic breast cancer
Lawrence G. Lum, Zaid Al-Kadhimi, Abhinav Deol, Vidya Kondadasula, Dana Schalk, Elyse Tomashewski, Patricia Steele, Kristie Fields, Melissa Giroux, Qin Liu, Lawrence Flaherty, Michael Simon, Archana Thakur

Journal for ImmunoTherapy of Cancer Jun 2021, 9 (6) e002194; DOI: 10.1136/jitc-2020-002194
IL-6 contributes to metastatic switch via the differentiation of monocytic-dendritic progenitors into prometastatic immune cells
Ksenia Magidey-Klein, Tim J Cooper, Ksenya Kveler, Rachelly Normand, Tongwu Zhang, Michael Timaner, Ziv Raviv, Brian P. James, Roi Gazit, Ze'ev A. Ronai, Shai Shen-Orr, Yuval Shaked

Journal for ImmunoTherapy of Cancer Jun 2021, 9 (6) e002856; DOI: 10.1136/jitc-2021-002856
Generation of a safe and efficacious llama single-domain antibody fragment (vHH) targeting the membrane-proximal region of 4-1BB for engineering therapeutic bispecific antibodies for cancer
Tianhang Zhai, Chao Wang, Yifeng Xu, Weifeng Huang, Zhijun Yuan, Tao Wang, Shuang Dai, Shaogang Peng, Tuling Pang, Wenchao Jiang, Yuhua Huang, Yuefeng Zou, Yingda Xu, Joanne Sun, Xinjiang Gong, Jinping Zhang, Andy Tsun, Bin Li, Xiaoniu Miao

Journal for ImmunoTherapy of Cancer Jun 2021, 9 (6) e002131; DOI: 10.1136/jitc-2020-002131

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