Open access

MER4 endogenous retrovirus correlated with better efficacy of anti-PD1/PD-L1 therapy in non-small cell lung cancer
Julie Lecuelle, Laure Favier, Cléa Fraisse, Aurélie Lagrange, Coureche Kaderbhai, Romain Boidot, Sandy Chevrier, Philippe Joubert, Bertrand Routy, Caroline Truntzer, Francois Ghiringhelli

Journal for ImmunoTherapy of Cancer Mar 2022, 10 (3) e004241; DOI: 10.1136/jitc-2021-004241
IL-1R8 silencing improves the anti-tumor function of freshly isolated human NK cells
Nadine Landolina, Francesca Romana Mariotti, Tiziano Ingegnere, Claudia Alicata, Biancamaria Ricci, Andrea Pelosi, Irene Veneziani, Bruno Giuseppe Azzarone, Cecilia Garlanda, Alberto Mantovani, Lorenzo Moretta, Enrico Maggi

Journal for ImmunoTherapy of Cancer Mar 2022, 10 (3) e003858; DOI: 10.1136/jitc-2021-003858
Development of a TCR-like antibody and chimeric antigen receptor against NY-ESO-1/HLA-A2 for cancer immunotherapy
Xin Liu, Yixiang Xu, Wei Xiong, Bingnan Yin, Yuqian Huang, Junjun Chu, Changsheng Xing, Chen Qian, Yang Du, Tianhao Duan, Helen Y Wang, Ningyan Zhang, John S. Yu, Zhiqiang An, Rongfu Wang

Journal for ImmunoTherapy of Cancer Mar 2022, 10 (3) e004035; DOI: 10.1136/jitc-2021-004035
Phase 2 trial of T-cell activation using MVI-816 and pembrolizumab in patients with metastatic, castration-resistant prostate cancer (mCRPC)
Douglas G McNeel, Jens C Eickhoff, Ellen Wargowski, Laura E Johnson, Christos E Kyriakopoulos, Hamid Emamekhoo, Joshua M Lang, Mary Jane Brennan, Glenn Liu

Journal for ImmunoTherapy of Cancer Mar 2022, 10 (3) e004198; DOI: 10.1136/jitc-2021-004198
Neoadjuvant in situ vaccination with cowpea mosaic virus as a novel therapy against canine inflammatory mammary cancer
Daniel Alonso-Miguel, Guillermo Valdivia, Diego Guerrera, Maria Dolores Perez-Alenza, Stanislav Pantelyushin, Angela Alonso-Diez, Veronique Beiss, Steven Fiering, Nicole F Steinmetz, Maria Suarez-Redondo, Johannes vom Berg, Laura Peña, Hugo Arias-Pulido

Journal for ImmunoTherapy of Cancer Mar 2022, 10 (3) e004044; DOI: 10.1136/jitc-2021-004044
Targeting of Cdc42 GTPase in regulatory T cells unleashes antitumor T-cell immunity
Khalid W Kalim, Jun-Qi Yang, Mark Wunderlich, Vishnu Modur, Phuong Nguyen, Yuan Li, Ting Wen, Ashley Kuenzi Davis, Ravinder Verma, Qing Richard Lu, Anil G Jegga, Yi Zheng, Fukun Guo

Journal for ImmunoTherapy of Cancer Nov 2022, 10 (11) e004806; DOI: 10.1136/jitc-2022-004806
Immune-based biomarker accurately predicts response to imiquimod immunotherapy in cervical high-grade squamous intraepithelial lesions
Ziena Abdulrahman, Natasja Hendriks, Arnold J Kruse, Antonios Somarakis, Anna J M van de Sande, Heleen J van Beekhuizen, Jurgen M J Piek, Noel F C C de Miranda, Loes F S Kooreman, Brigitte F M Slangen, Sjoerd H van der Burg, Peggy J de Vos van Steenwijk, Edith M G van Esch

Journal for ImmunoTherapy of Cancer Nov 2022, 10 (11) e005288; DOI: 10.1136/jitc-2022-005288
Both APRIL and antibody-fragment-based CAR T cells for myeloma induce BCMA downmodulation by trogocytosis and internalization
Nicolas Camviel, Benita Wolf, Giancarlo Croce, David Gfeller, Vincent Zoete, Caroline Arber

Journal for ImmunoTherapy of Cancer Nov 2022, 10 (11) e005091; DOI: 10.1136/jitc-2022-005091
Patient-derived Siglec-6-targeting antibodies engineered for T-cell recruitment have potential therapeutic utility in chronic lymphocytic leukemia
Matthew G Cyr, Maissa Mhibik, Junpeng Qi, Haiyong Peng, Jing Chang, Erika M Gaglione, David Eik, John Herrick, Thomas Venables, Scott J Novick, Valentine V Courouble, Patrick R Griffin, Adrian Wiestner, Christoph Rader

Journal for ImmunoTherapy of Cancer Nov 2022, 10 (11) e004850; DOI: 10.1136/jitc-2022-004850
Gut microbiome-depleting antibiotic regimens are not tolerated by all mouse strains: learn from (our) bitter experience
Andrew A Almonte, George Cavic, Teresa Neeman, Anselm Enders, Aude M Fahrer

Journal for ImmunoTherapy of Cancer Nov 2022, 10 (11) e005575; DOI: 10.1136/jitc-2022-005575

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