Open access

371 Distinct predictive value of CD137 as a tumor reactive marker among different cancer types and TIL expansion stage
Zhenjiang Liu, Jingwei Sun, Zixiao Shi, Peipei Zhao, Quanwei Wang, Xu Wang, Pin Wang, Yarong Liu

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A421; DOI: 10.1136/jitc-2023-SITC2023.0371
372 TAC-T cells persist and remain functional during and after repeated tumor exposure in vitro and in vivo
Heather L MacGregor, Suzanna L Prosser, Stacey X Xu, Kyle MacDonald, Aksha Kadri, Ritu R Randhawa, Swati Shetty, Sailaja Pirati, Deepika Bhemarasetty, Christopher W Helsen, Sadhak Sengupta, Andreas G Bader

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A422; DOI: 10.1136/jitc-2023-SITC2023.0372
374 Discovery of mutant IDH1 reactive T cell receptors for transgenic T cell therapy
Julius Michel, Khwab Sanghvi, Katharina Lindner, Amelie Dietsch, Kristine Jähne, Theresa Bunse, Wolfgang Wick, Lukas Bunse, Michael Platten

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A423; DOI: 10.1136/jitc-2023-SITC2023.0374
375 Enhanced anti-tumor activity and T-cell fitness of 2^nd-generation MAGE-A1 TCR T-cells incorporating distinct CD8 co-receptor designs
Paul Najm, Josephine Kemna, Friederike Knipping, Marleen van Loenen, Panagiota A Sotiropoulou, Mikhail Steklov

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A424; DOI: 10.1136/jitc-2023-SITC2023.0375
376 Overcoming tumor heterogeneity – Clinical trial assays to prospectively assign patients customized multiplexed TCR-T cell therapy in Phase 1
Ribhu Nayar, Shazad A Khokhar, Sonal Jangalwe, Sveta Padmanabhan, Nancy Nabilsi, Teagan Parsons, Jeffrey Coleman, Adam Hsiung, Chunghun Chang, Henry Tsai, Shehla Arain, Ariane Lozac’hmeur, Andrew Nguyen, Jessica Rathbun, Qidi Yang, Ruey Pham, Sam Harris, Shardul Soni, Tyler Danek, Katie Marshall, Amanda Jensen, Chris Riley, Livio Dukaj, Alexander Cristofaro, Yun Wang, Erica Buonomo, Cagan Gurer, Antoine J Boudot, Shrikanta Chattopadhyay, Debora Barton, Gavin MacBeath

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A425; DOI: 10.1136/jitc-2023-SITC2023.0376
378 Development of a clinical candidate TCR for mutant KRAS using a high-precision cell-based platform
Luke Pase, Hugh Salter, Anette Brass, Daniela Casarrubea, Josefine Dunst, Sara Horta, Miriam Masia-Balague, Tiphane Parrot, Athina Totomi, Hannes Uchtenhagen, Shenqiu Wang, Ryan Hill, Reagan Jarvis

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A427; DOI: 10.1136/jitc-2023-SITC2023.0378
380 Exploring the microenvironment of clear cell renal cell carcinoma to improve therapy with tumor infiltrating lymphocytes
Marine Potez, Mohammed Alkhouli, Johannes Ali, Michael I Carter, Fatema Khambati, Matthew Beatty, Jad Chahoud, Shari Pilon-Thomas

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A429; DOI: 10.1136/jitc-2023-SITC2023.0380
381 SUPLEXA, a multimodal autologous cellular therapy, shows immunomodulatory behavior in cancer patients consistent with improved anti-tumor immune function
John F Pulford, Ekaterina Murzin, Daniel Younger, Rohit Joshi, Jeffrey Goh, Ganessan Kichenadasse, Sharron Gargosky, Frank Borriello, James A Lederer

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A430; DOI: 10.1136/jitc-2023-SITC2023.0381
382 TIM-3 blockade combined with adoptive therapy of ex vivo activated NK cells after allogeneic hematopoietic stem cell transplant reduces progression of relapsed murine neuroblastoma
Aicha Quamine, Nicholas R Mohrdieck, Chloe A King, Anastasia A Griggs, Katharine E Tippins, Paul D Bates, Nicholas J Hess, Tyce J Kearl, Bryon D Johnson, Christian Capitini

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A431; DOI: 10.1136/jitc-2023-SITC2023.0382
383 Radiotherapy, tumor-specific antibodies, and autologous NK/Macrophage cell therapy enhance anti-tumor immunity in metastatic pancreatic cancer
Mahfuzur Rahman, Andrea Pennati, Zafer Gurel, Randall Kimple, Christian Capitini, Jacques Galipeau, Zachary Morris

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A432; DOI: 10.1136/jitc-2023-SITC2023.0383

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