Journal for ImmunoTherapy of Cancer

Caspase-9 inhibition triggers Hsp90-based chemotherapy-mediated tumor intrinsic innate sensing and enhances antitumor immunity
Jingyang Li, Xiaoyu Han, Mayu Sun, Weida Li, Guanghuan Yang, Huiyi Chen, Bao Guo, Jingquan Li, Xiaoguang Li, Hui Wang

Journal for ImmunoTherapy of Cancer Dec 2023, 11 (12) e007625; DOI: 10.1136/jitc-2023-007625
Fibrinogen-like protein 2 promotes tumor immune suppression by regulating cholesterol metabolism in myeloid-derived suppressor cells
Lei Wu, Xudong Liu, Juan Lei, Nan Zhang, Huakan Zhao, Jiangang Zhang, Huan Deng, Yongsheng Li

Journal for ImmunoTherapy of Cancer Dec 2023, 11 (12) e008081; DOI: 10.1136/jitc-2023-008081
iPSC-derived natural killer cells expressing the FcγR fusion CD64/16A can be armed with antibodies for multitumor antigen targeting
Kristin M Snyder, Kate J Dixon, Zachary Davis, Martin Hosking, Geoffrey Hart, Melissa Khaw, Anders Matson, Ryan Bjordahl, Bryan Hancock, Soheila Shirinbak, Jeffrey S Miller, Bahram Valamehr, Jianming Wu, Bruce Walcheck

Journal for ImmunoTherapy of Cancer Dec 2023, 11 (12) e007280; DOI: 10.1136/jitc-2023-007280
Tumor cell-intrinsic SETD2 inactivation sensitizes cancer cells to immune checkpoint blockade through the NR2F1-STAT1 pathway
Xufen Zheng, Yuxiang Luo, Yangjie Xiong, Xiaoxiao Liu, Chunling Zeng, Xiaojing Lu, Xiaofang Wang, Yumei Cheng, Simin Wang, Haoqi Lan, Kai Wang, Zhonghui Weng, Wenbo Bi, Xinxin Gan, Xiaona Jia, Linhui Wang, Yuexiang Wang

Journal for ImmunoTherapy of Cancer Dec 2023, 11 (12) e007678; DOI: 10.1136/jitc-2023-007678
CXCL10 and Nrf2-upregulated mesenchymal stem cells reinvigorate T lymphocytes for combating glioblastoma
Jiaji Mao, Jianing Li, Junwei Chen, Qin Wen, Minghui Cao, Fang Zhang, Baoxun Li, Qinyuan Zhang, Zhe Wang, Jingzhong Zhang, Jun Shen

Journal for ImmunoTherapy of Cancer Dec 2023, 11 (12) e007481; DOI: 10.1136/jitc-2023-007481
Differential requirements for CD4+ T cells in the efficacy of the anti-PD-1+LAG-3 and anti-PD-1+CTLA-4 combinations in melanoma flank and brain metastasis models
Manali S Phadke, Jiannong Li, Zhihua Chen, Paulo C Rodriguez, Jessica K Mandula, Lilit Karapetyan, Peter A Forsyth, Y Ann Chen, Keiran S M Smalley

Journal for ImmunoTherapy of Cancer Dec 2023, 11 (12) e007239; DOI: 10.1136/jitc-2023-007239
Dynamical modeling of proliferative-invasive plasticity and IFNγ signaling in melanoma reveals mechanisms of PD-L1 expression heterogeneity
Seemadri Subhadarshini, Sarthak Sahoo, Shibjyoti Debnath, Jason A Somarelli, Mohit Kumar Jolly

Journal for ImmunoTherapy of Cancer Sep 2023, 11 (9) e006766; DOI: 10.1136/jitc-2023-006766
Bispecific antibody CD73xEGFR more selectively inhibits the CD73/adenosine immune checkpoint on cancer cells and concurrently counteracts pro-oncogenic activities of CD73 and EGFR
Emily Maria Ploeg, Douwe Freerk Samplonius, Xiao Xiong, Xiurong Ke, Mark Alexander Johannes Martinus Hendriks, Isabel Britsch, Anne Paulien van Wijngaarden, Hao Zhang, Wijnand Helfrich

Journal for ImmunoTherapy of Cancer Sep 2023, 11 (9) e006837; DOI: 10.1136/jitc-2023-006837
Inhibition of TCA cycle improves the anti-PD-1 immunotherapy efficacy in melanoma cells via ATF3-mediated PD-L1 expression and glycolysis
Nian Liu, Mingjie Yan, Qian Tao, Jie Wu, Jing Chen, Xiang Chen, Cong Peng

Journal for ImmunoTherapy of Cancer Sep 2023, 11 (9) e007146; DOI: 10.1136/jitc-2023-007146
Polymorphonuclear myeloid-derived suppressor cells and phosphatidylinositol-3 kinase gamma are critical to tobacco-mimicking oral carcinogenesis in mice
Khoa A Nguyen, Lisa N DePledge, Li Bian, Yao Ke, Von Samedi, Amber A Berning, Philip Owens, Xiao-Jing Wang, Christian D Young

Journal for ImmunoTherapy of Cancer Sep 2023, 11 (9) e007110; DOI: 10.1136/jitc-2023-007110

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