JITC

Chimeric antigen receptor T cells engineered to recognize the P329G-mutated Fc part of effector-silenced tumor antigen-targeting human IgG1 antibodies enable modular targeting of solid tumors
Sophia Stock, Mohamed-Reda Benmebarek, Anna-Kristina Kluever, Diana Darowski, Christian Jost, Kay-Gunnar Stubenrauch, Joerg Benz, Anne Freimoser-Grundschober, Ekkehard Moessner, Pablo Umana, Marion Subklewe, Stefan Endres, Christian Klein, Sebastian Kobold

Journal for ImmunoTherapy of Cancer Jul 2022, 10 (7) e005054; DOI: 10.1136/jitc-2022-005054
Influence of tumor mutational burden, inflammatory gene expression profile, and PD-L1 expression on response to pembrolizumab in head and neck squamous cell carcinoma
Robert I Haddad, Tanguy Y Seiwert, Laura Q M Chow, Shilpa Gupta, Jared Weiss, Iris Gluck, Joseph P Eder, Barbara Burtness, Makoto Tahara, Bhumsuk Keam, Hyunseok Kang, Kei Muro, Andrew Albright, Robin Mogg, Mark Ayers, Lingkang Huang, Jared Lunceford, Razvan Cristescu, Jonathan Cheng, Ranee Mehra

Journal for ImmunoTherapy of Cancer Feb 2022, 10 (2) e003026; DOI: 10.1136/jitc-2021-003026
Generalizable design parameters for soluble T cell receptor-based T cell engagers
Karen J Froning, Arlene Sereno, Flora Huang, Stephen J Demarest

Journal for ImmunoTherapy of Cancer Mar 2022, 10 (3) e004281; DOI: 10.1136/jitc-2021-004281
JAK and mTOR inhibitors prevent cytokine release while retaining T cell bispecific antibody in vivo efficacy
Gabrielle Leclercq, Hélène Haegel, Alberto Toso, Tina Zimmermann, Luke Green, Nathalie Steinhoff, Johannes Sam, Vesna Pulko, Anneliese Schneider, Anna Maria Giusti, John Challier, Anne Freimoser-Grundschober, Laurent Larivière, Alex Odermatt, Martin Stern, Pablo Umana, Marina Bacac, Christian Klein

Journal for ImmunoTherapy of Cancer Jan 2022, 10 (1) e003766; DOI: 10.1136/jitc-2021-003766
Mesothelin-specific CAR-T cell therapy that incorporates an HLA-gated safety mechanism selectively kills tumor cells
Talar Tokatlian, Grace E Asuelime, Jee-Young Mock, Breanna DiAndreth, Shruti Sharma, Dora Toledo Warshaviak, Mark E Daris, Kristian Bolanos, Breanna L Luna, Martin S Naradikian, Kiran Deshmukh, Agnes E Hamburger, Alexander Kamb

Journal for ImmunoTherapy of Cancer Jan 2022, 10 (1) e003826; DOI: 10.1136/jitc-2021-003826
TIM-3 blockade enhances IL-12-dependent antitumor immunity by promoting CD8⁺ T cell and XCR1⁺ dendritic cell spatial co-localization
Alycia Gardner, Álvaro de Mingo Pulido, Kay Hänggi, Sarah Bazargan, Alexis Onimus, Agnieszka Kasprzak, Jose R Conejo-Garcia, Katarzyna A Rejniak, Brian Ruffell

Journal for ImmunoTherapy of Cancer Jan 2022, 10 (1) e003571; DOI: 10.1136/jitc-2021-003571
CCR1 and CCR5 mediate cancer-induced myelopoiesis and differentiation of myeloid cells in the tumor
Serena Zilio, Silvio Bicciato, Donald Weed, Paolo Serafini

Journal for ImmunoTherapy of Cancer Jan 2022, 10 (1) e003131; DOI: 10.1136/jitc-2021-003131
Germline biomarkers predict toxicity to anti-PD1/PDL1 checkpoint therapy
Joanne Weidhaas, Nicholas Marco, Aaron W Scheffler, Anusha Kalbasi, Kirk Wilenius, Emily Rietdorf, Jaya Gill, Mara Heilig, Caroline Desler, Robert K Chin, Tania Kaprealian, Susan McCloskey, Ann Raldow, Naga P Raja, Santosh Kesari, Jose Carrillo, Alexandra Drakaki, Mark Scholz, Donatello Telesca

Journal for ImmunoTherapy of Cancer Feb 2022, 10 (2) e003625; DOI: 10.1136/jitc-2021-003625
Immuno-oncology trends: preclinical models, biomarkers, and clinical development
Maryland Rosenfeld Franklin, Suso Platero, Kamal S Saini, Giuseppe Curigliano, Steven Anderson

Journal for ImmunoTherapy of Cancer Jan 2022, 10 (1) e003231; DOI: 10.1136/jitc-2021-003231
Safety and antitumor activity of dostarlimab in patients with advanced or recurrent DNA mismatch repair deficient/microsatellite instability-high (dMMR/MSI-H) or proficient/stable (MMRp/MSS) endometrial cancer: interim results from GARNET—a phase I, single-arm study
Ana Oaknin, Lucy Gilbert, Anna V Tinker, Jubilee Brown, Cara Mathews, Joshua Press, Renaud Sabatier, David M O’Malley, Vanessa Samouelian, Valentina Boni, Linda Duska, Sharad Ghamande, Prafull Ghatage, Rebecca Kristeleit, Charles Leath III, Wei Guo, Ellie Im, Sybil Zildjian, Xinwei Han, Tao Duan, Jennifer Veneris, Bhavana Pothuri

Journal for ImmunoTherapy of Cancer Jan 2022, 10 (1) e003777; DOI: 10.1136/jitc-2021-003777

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