Immunotherapy Biomarkers

Clinical significance of plasma-free amino acids and tryptophan metabolites in patients with non-small cell lung cancer receiving PD-1 inhibitor: a pilot cohort study for developing a prognostic multivariate model
Koichi Azuma, Huihui Xiang, Tomoyuki Tagami, Rika Kasajima, Yumiko Kato, Sachise Karakawa, Shinya Kikuchi, Akira Imaizumi, Norikazu Matsuo, Hidenobu Ishii, Takaaki Tokito, Akihiko Kawahara, Kenta Murotani, Tetsuro Sasada, Yohei Miyagi, Tomoaki Hoshino

Journal for ImmunoTherapy of Cancer May 2022, 10 (5) e004420; DOI: 10.1136/jitc-2021-004420
Paired primary and metastatic lesions of patients with ipilimumab-treated melanoma: high variation in lymphocyte infiltration and HLA-ABC expression whereas tumor mutational load is similar and correlates with clinical outcome
Mark A J Gorris, Lieke L van der Woude, Leonie I Kroeze, Kalijn Bol, Kiek Verrijp, Avital L Amir, Jelena Meek, Johannes Textor, Carl G Figdor, I Jolanda M de Vries

Journal for ImmunoTherapy of Cancer May 2022, 10 (5) e004329; DOI: 10.1136/jitc-2021-004329
NKG2A and PD-L1 expression panel predicts clinical benefits from adjuvant chemotherapy and PD-L1 blockade in muscle-invasive bladder cancer
Sen Yan, Han Zeng, Kaifeng Jin, Fei Shao, Zhaopei Liu, Yuan Chang, Yiwei Wang, Yu Zhu, Zewei Wang, Le Xu, Jiejie Xu

Journal for ImmunoTherapy of Cancer May 2022, 10 (5) e004569; DOI: 10.1136/jitc-2022-004569
Genomic profiling of advanced cervical cancer to predict response to programmed death-1 inhibitor combination therapy: a secondary analysis of the CLAP trial
Xin Huang, Minjun He, Hongyu Peng, Chongjie Tong, Zhimin Liu, Xiaolong Zhang, Yang Shao, Dongqin Zhu, Junli Zhang, Jiani C Yin, Fan Yang, Chunyan Lan

Journal for ImmunoTherapy of Cancer May 2021, 9 (5) e002223; DOI: 10.1136/jitc-2020-002223
On-treatment immune prognostic score for patients with relapsed and/or metastatic head and neck squamous cell carcinoma treated with immunotherapy
Pablo Nenclares, Lucinda Gunn, Heba Soliman, Mateo Bover, Amy Trinh, Isla Leslie, Kee Howe Wong, Alan Melcher, Kate Newbold, Chris M Nutting, Derfel ap Dafydd, Shreerang A Bhide, Kevin Harrington

Journal for ImmunoTherapy of Cancer Jun 2021, 9 (6) e002718; DOI: 10.1136/jitc-2021-002718
Pan-cancer analysis of CD274 (PD-L1) mutations in 314,631 patient samples and subset correlation with PD-L1 protein expression
Richard S.P. Huang, Brennan Decker, Karthikeyan Murugesan, Matthew Hiemenz, Douglas A. Mata, Gerald Li, James Creeden, Shakti H. Ramkissoon, Jeffrey S. Ross

Journal for ImmunoTherapy of Cancer Jun 2021, 9 (6) e002558; DOI: 10.1136/jitc-2021-002558
Immune landscape and subtypes in primary resectable oral squamous cell carcinoma: prognostic significance and predictive of therapeutic response
Pengfei Diao, Yue Jiang, Yuanyuan Li, Xiang Wu, Jin Li, Chen Zhou, Lei Jiang, Wei Zhang, Enshi Yan, Ping Zhang, Xu Ding, Heming Wu, Hua Yuan, Jinhai Ye, Xiaomeng Song, Linzhong Wan, Yunong Wu, Hongbing Jiang, Yanling Wang, Jie Cheng

Journal for ImmunoTherapy of Cancer Jun 2021, 9 (6) e002434; DOI: 10.1136/jitc-2021-002434
Non-invasive measurement of PD-L1 status and prediction of immunotherapy response using deep learning of PET/CT images
Wei Mu, Lei Jiang, Yu Shi, Ilke Tunali, Jhanelle E Gray, Evangelia Katsoulakis, Jie Tian, Robert J Gillies, Matthew B Schabath

Journal for ImmunoTherapy of Cancer Jun 2021, 9 (6) e002118; DOI: 10.1136/jitc-2020-002118
Massive PD-L1 and CD8 double positive TILs characterize an immunosuppressive microenvironment with high mutational burden in lung cancer
Libin Zhang, Yanhui Chen, Han Wang, Zheyuan Xu, Yang Wang, Sixing Li, Jun Liu, Yun Chen, Hongli Luo, Lijia Wu, Ying Yang, Henghui Zhang, Hao Peng

Journal for ImmunoTherapy of Cancer Jun 2021, 9 (6) e002356; DOI: 10.1136/jitc-2021-002356
Novel non-terminal tumor sampling procedure using fine needle aspiration supports immuno-oncology biomarker discovery in preclinical mouse models
Suzanne Isabelle Sitnikova, Sophie Munnings-Tomes, Elena Galvani, Stacy Kentner, Kathy Mulgrew, Chris Rands, Judit España Agustí, Tianhui Zhang, Kristina M Ilieva, Guglielmo Rosignoli, Hormas Ghadially, Matthew J Robinson, Tim Slidel, Robert W Wilkinson, Simon J Dovedi

Journal for ImmunoTherapy of Cancer Jun 2021, 9 (6) e002894; DOI: 10.1136/jitc-2021-002894

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