Clinical/Translational Cancer Immunotherapy

Complete metabolic response in patients with advanced non-small cell lung cancer with prolonged response to immune checkpoint inhibitor therapy
Justin Ferdinandus, Martin Metzenmacher, Lukas Kessler, Lale Umutlu, Clemens Aigner, Karl-Otto Kambartel, Viktor Grünwald, Wilfried Ernst Erich Eberhardt, Wolfgang Peter Fendler, Ken Herrmann, Martin Faehling, Daniel Christian Christoph

Journal for ImmunoTherapy of Cancer Mar 2021, 9 (3) e002262; DOI: 10.1136/jitc-2020-002262
Clinical and immunologic impact of short-course enzalutamide alone and with immunotherapy in non-metastatic castration sensitive prostate cancer
Ravi A Madan, Fatima Karzai, Renee N Donahue, Munjid Al-Harthy, Marijo Bilusic, Inger I Rosner, Harpreet Singh, Philip M Arlen, Marc R Theoret, Jennifer L Marté, Lisa Cordes, Anna Couvillon, Amy Hankin, Moniquea Williams, Helen Owens, Sarah E Lochrin, Cindy H Chau, Seth Steinberg, William Douglas Figg, William Dahut, Jeffrey Schlom, James L Gulley

Journal for ImmunoTherapy of Cancer Mar 2021, 9 (3) e001556; DOI: 10.1136/jitc-2020-001556
Complement C3a and C5a receptor blockade modulates regulatory T cell conversion in head and neck cancer
Jacob Gadwa, Thomas E Bickett, Laurel B Darragh, Michael William Knitz, Shilpa Bhatia, Miles Piper, Benjamin Van Court, Shiv Bhuvane, Diemmy Nguyen, Varuna Nangia, Emily K Kleczko, Raphael A Nemenoff, Sana D Karam

Journal for ImmunoTherapy of Cancer Mar 2021, 9 (3) e002585; DOI: 10.1136/jitc-2021-002585
Releasing the brakes of tumor immunity with anti-PD-L1 and pushing its accelerator with L19–IL2 cures poorly immunogenic tumors when combined with radiotherapy
Veronica Olivo Pimentel, Damiënne Marcus, Alexander MA van der Wiel, Natasja G Lieuwes, Rianne Biemans, Relinde IY Lieverse, Dario Neri, Jan Theys, Ala Yaromina, Ludwig J Dubois, Philippe Lambin

Journal for ImmunoTherapy of Cancer Mar 2021, 9 (3) e001764; DOI: 10.1136/jitc-2020-001764
Circulating cytokines associated with clinical response to systemic therapy in metastatic renal cell carcinoma
Alexander Chehrazi-Raffle, Luis Meza, Marice Alcantara, Nazli Dizman, Paulo Bergerot, Nicholas Salgia, JoAnn Hsu, Nora Ruel, Sabrina Salgia, Jasnoor Malhotra, Ewa Karczewska, Marcin Kortylewski, Sumanta Pal

Journal for ImmunoTherapy of Cancer Mar 2021, 9 (3) e002009; DOI: 10.1136/jitc-2020-002009
Safety and activity of the TGFβ receptor I kinase inhibitor galunisertib plus the anti-PD-L1 antibody durvalumab in metastatic pancreatic cancer
Davide Melisi, Do-Youn Oh, Antoine Hollebecque, Emiliano Calvo, Anna Varghese, Erkut Borazanci, Teresa Macarulla, Valeria Merz, Camilla Zecchetto, Yumin Zhao, Ivelina Gueorguieva, Michael Man, Leena Gandhi, Shawn T Estrem, Karim A Benhadji, Mark C Lanasa, Emin Avsar, Susan C Guba, Rocio Garcia-Carbonero

Journal for ImmunoTherapy of Cancer Mar 2021, 9 (3) e002068; DOI: 10.1136/jitc-2020-002068
Host response to immune checkpoint inhibitors contributes to tumor aggressiveness
Irina Khononov, Eyal Jacob, Ella Fremder, Nili Dahan, Michal Harel, Ziv Raviv, Boris Krastev, Yuval Shaked

Journal for ImmunoTherapy of Cancer Mar 2021, 9 (3) e001996; DOI: 10.1136/jitc-2020-001996
Anti-GD2 antibody dinutuximab inhibits triple-negative breast tumor growth by targeting GD2⁺ breast cancer stem-like cells
Stanley Ly, Vivek Anand, Fouad El-Dana, Khoa Nguyen, Yiming Cai, Shirong Cai, Helen Piwnica-Worms, Debasish Tripathy, Aysegul A Sahin, Michael Andreeff, Venkata Lokesh Battula

Journal for ImmunoTherapy of Cancer Mar 2021, 9 (3) e001197; DOI: 10.1136/jitc-2020-001197
Human CD141⁺ dendritic cells (cDC1) are impaired in patients with advanced melanoma but can be targeted to enhance anti-PD-1 in a humanized mouse model
Yoke Seng Lee, Liam J O'Brien, Carina M Walpole, Frances E Pearson, Ingrid M Leal-Rojas, Kelly-Anne Masterman, Victoria Atkinson, Andrew Barbour, Kristen J Radford

Journal for ImmunoTherapy of Cancer Mar 2021, 9 (3) e001963; DOI: 10.1136/jitc-2020-001963
Primary results from TAIL: a global single-arm safety study of atezolizumab monotherapy in a diverse population of patients with previously treated advanced non-small cell lung cancer
Andrea Ardizzoni, Sergio Azevedo, Belen Rubio-Viqueira, Delvys Rodríguez-Abreu, Jorge Alatorre-Alexander, Hans J M Smit, Jinming Yu, Konstantinos Syrigos, Kerstin Trunzer, Hina Patel, Jonathan Tolson, Andres Cardona, Pablo D Perez-Moreno, Tom Newsom-Davis

Journal for ImmunoTherapy of Cancer Mar 2021, 9 (3) e001865; DOI: 10.1136/jitc-2020-001865

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