Clinical/Translational Cancer Immunotherapy

Phase II, single-arm trial of preoperative short-course radiotherapy followed by chemotherapy and camrelizumab in locally advanced rectal cancer
Zhenyu Lin, Ming Cai, Peng Zhang, Gang Li, Tao Liu, Xin Li, Kailin Cai, Xiu Nie, Jing Wang, Junli Liu, Hongli Liu, Weikang Zhang, Jingbo Gao, Chuanqing Wu, Linfang Wang, Jun Fan, Lan Zhang, Zheng Wang, Zhiguo Hou, Chi Ma, Kunyu Yang, Gang Wu, Kaixiong Tao, Tao Zhang

Journal for ImmunoTherapy of Cancer Nov 2021, 9 (11) e003554; DOI: 10.1136/jitc-2021-003554
Virological breakthrough after immune checkpoint inhibitor and nucleos(t)ide analog treatment in patients with hepatitis B surface antigen positive hepatocellular carcinoma: a real-world study
Kunyuan Wang, Ying Xia, Yun Zhu, Wenxuan Yu, Yabing Guo, Li Liu

Journal for ImmunoTherapy of Cancer Nov 2021, 9 (11) e003195; DOI: 10.1136/jitc-2021-003195
Selective IL-1 activity on CD8⁺ T cells empowers antitumor immunity and synergizes with neovasculature-targeted TNF for full tumor eradication
Bram Van Den Eeckhout, Leander Huyghe, Sandra Van Lint, Elianne Burg, Stéphane Plaisance, Frank Peelman, Anje Cauwels, Gilles Uzé, Niko Kley, Sarah Gerlo, Jan Tavernier

Journal for ImmunoTherapy of Cancer Nov 2021, 9 (11) e003293; DOI: 10.1136/jitc-2021-003293
Combining CTLA-4 and angiopoietin-2 blockade in patients with advanced melanoma: a phase I trial
Patrick A Ott, Matthew Nazzaro, Kathleen L Pfaff, Evisa Gjini, Kristen D Felt, Jacquelyn O Wolff, Elizabeth I Buchbinder, Rizwan Haq, Ryan J Sullivan, Donald P Lawrence, David F McDermott, Mariano Severgnini, Anita Giobbie-Hurder, Scott J Rodig, F Stephen Hodi

Journal for ImmunoTherapy of Cancer Nov 2021, 9 (11) e003318; DOI: 10.1136/jitc-2021-003318
Combination immunotherapy with nivolumab and ipilimumab in patients with rare gynecological malignancies: results of the CA209-538 clinical trial
Oliver Klein, Damien Kee, Bo Gao, Ben Markman, Jessica da Gama Duarte, Luke Quigley, Louise Jackett, Richelle Linklater, Andrew Strickland, Clare Scott, Linda Mileshkin, Jodie Palmer, Matteo Carlino, Andreas Behren, Jonathan Cebon

Journal for ImmunoTherapy of Cancer Nov 2021, 9 (11) e003156; DOI: 10.1136/jitc-2021-003156
Fc-comprising scDb-based trivalent, bispecific T-cell engagers for selective killing of HER3-expressing cancer cells independent of cytokine release
Nadine Aschmoneit, Lennart Kühl, Oliver Seifert, Roland E Kontermann

Journal for ImmunoTherapy of Cancer Nov 2021, 9 (11) e003616; DOI: 10.1136/jitc-2021-003616
Dendritic cell vaccines targeting tumor blood vessel antigens in combination with dasatinib induce therapeutic immune responses in patients with checkpoint-refractory advanced melanoma
Walter J Storkus, Deena Maurer, Yan Lin, Fei Ding, Anamika Bose, Devin Lowe, Amy Rose, Melissa DeMark, Lilit Karapetyan, Jennifer L Taylor, Manoj Chelvanambi, Ronald J Fecek, Jessica N Filderman, Timothy J Looney, Lauren Miller, Elizabeth Linch, Geoffrey M Lowman, Pawel Kalinski, Lisa H Butterfield, Ahmad Tarhini, Hussein Tawbi, John M Kirkwood

Journal for ImmunoTherapy of Cancer Nov 2021, 9 (11) e003675; DOI: 10.1136/jitc-2021-003675
Toripalimab plus intensity-modulated radiotherapy for recurrent nasopharyngeal carcinoma: an open-label single-arm, phase II trial
Yijun Hua, Rui You, Zhiqiang Wang, Peiyu Huang, Mei Lin, Yanfeng Ouyang, Yulong Xie, Xiong Zou, Youping Liu, Chongyang Duan, Yonglong Liu, Chenmei Gu, Rongzeng Liu, Qi Yang, Rou Jiang, Mengxia Zhang, Xi Ding, Siyuan Chen, Chao Lin, Rui Sun, Mingyuan Chen

Journal for ImmunoTherapy of Cancer Nov 2021, 9 (11) e003290; DOI: 10.1136/jitc-2021-003290
CD73 and PD-L1 dual blockade amplifies antitumor efficacy of SBRT in murine PDAC models
Jian Ye, Nicholas W Gavras, David C Keeley, Angela L Hughson, Gary Hannon, Tara G Vrooman, Maggie L Lesch, Carl J Johnston, Edith M Lord, Brian A Belt, David C Linehan, Jim Eyles, Scott A Gerber

Journal for ImmunoTherapy of Cancer May 2023, 11 (5) e006842; DOI: 10.1136/jitc-2023-006842
Talimogene laherparepvec in combination with ipilimumab versus ipilimumab alone for advanced melanoma: 5-year final analysis of a multicenter, randomized, open-label, phase II trial
Jason A Chesney, Igor Puzanov, Frances A Collichio, Parminder Singh, Mohammed M Milhem, John Glaspy, Omid Hamid, Merrick Ross, Philip Friedlander, Claus Garbe, Theodore Logan, Axel Hauschild, Celeste Lebbé, Harshada Joshi, Wendy Snyder, Janice M Mehnert

Journal for ImmunoTherapy of Cancer May 2023, 11 (5) e006270; DOI: 10.1136/jitc-2022-006270

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