Clinical/Translational Cancer Immunotherapy

Anti-TGF-β/PD-L1 bispecific antibody promotes T cell infiltration and exhibits enhanced antitumor activity in triple-negative breast cancer
Ming Yi, Yuze Wu, Mengke Niu, Shuangli Zhu, Jing Zhang, Yongxiang Yan, Pengfei Zhou, Zhijun Dai, Kongming Wu

Journal for ImmunoTherapy of Cancer Dec 2022, 10 (12) e005543; DOI: 10.1136/jitc-2022-005543
Targeting CD89 on tumor-associated macrophages overcomes resistance to immune checkpoint blockade
Lijun Xu, Bingyu Li, Chenyu Pi, Zhaohua Zhu, Fei Tao, Kun Xie, Yan Feng, Xiaoqing Xu, Yanxin Yin, Hua Gu, Jianmin Fang

Journal for ImmunoTherapy of Cancer Dec 2022, 10 (12) e005447; DOI: 10.1136/jitc-2022-005447
GPC2 antibody–drug conjugate reprograms the neuroblastoma immune milieu to enhance macrophage-driven therapies
Guillem Pascual-Pasto, Brendan McIntyre, Rawan Shraim, Samantha N Buongervino, Amy K Erbe, Doncho V Zhelev, Shakhnozakhon Sadirova, Anna M Giudice, Daniel Martinez, Laura Garcia-Gerique, Dimiter S Dimitrov, Paul M Sondel, Kristopher R Bosse

Journal for ImmunoTherapy of Cancer Dec 2022, 10 (12) e004704; DOI: 10.1136/jitc-2022-004704
Outcomes of stage IV melanoma in the era of immunotherapy: a National Cancer Database (NCDB) analysis from 2014 to 2016
Tamara A Sussman, Rebecca Knackstedt, Wei Wei, Pauline Funchain, Brian R Gastman

Journal for ImmunoTherapy of Cancer Aug 2022, 10 (8) e004994; DOI: 10.1136/jitc-2022-004994
Anti-CD73 antibody activates human B cells, enhances humoral responses and induces redistribution of B cells in patients with cancer
Richard A Miller, Jason John Luke, Shenshen Hu, Suresh Mahabhashyam, William B Jones, Thomas Marron, Jaime R Merchan, Brett G M Hughes, Stephen B Willingham

Journal for ImmunoTherapy of Cancer Dec 2022, 10 (12) e005802; DOI: 10.1136/jitc-2022-005802
Prognostic value of tumor-associated N1/N2 neutrophil plasticity in patients following radical resection of pancreas ductal adenocarcinoma
Qiangda Chen, Hanlin Yin, Siyao Liu, Sami Shoucair, Ni Ding, Yuan Ji, Jicheng Zhang, Dansong Wang, Tiantao Kuang, Xuefeng Xu, Jun Yu, Wenchuan Wu, Ning Pu, Wenhui Lou

Journal for ImmunoTherapy of Cancer Dec 2022, 10 (12) e005798; DOI: 10.1136/jitc-2022-005798
Modeling resistance of colorectal peritoneal metastases to immune checkpoint blockade in humanized mice
Emre Küçükköse, Balthasar A Heesters, Julien Villaudy, André Verheem, Madalina Cercel, Susan van Hal, Sylvia F Boj, Inne H M Borel Rinkes, Cornelis J A Punt, Jeanine M L Roodhart, Jamila Laoukili, Miriam Koopman, Hergen Spits, Onno Kranenburg

Journal for ImmunoTherapy of Cancer Dec 2022, 10 (12) e005345; DOI: 10.1136/jitc-2022-005345
Interleukin-10 induces expression of CD39 on CD8+T cells to potentiate anti-PD1 efficacy in EGFR-mutated non-small cell lung cancer
Meng Qiao, Fei Zhou, Xinyu Liu, Tao Jiang, Haowei Wang, Yijun Jia, Xuefei Li, Chao Zhao, Lei Cheng, Xiaoxia Chen, Shengxiang Ren, Hongcheng Liu, Caicun Zhou

Journal for ImmunoTherapy of Cancer Dec 2022, 10 (12) e005436; DOI: 10.1136/jitc-2022-005436
TIGIT blockade repolarizes AML-associated TIGIT⁺ M2 macrophages to an M1 phenotype and increases CD47-mediated phagocytosis
Franziska Brauneck, Brit Fischer, Marius Witt, Jana Muschhammer, Jennyfer Oelrich, Pedro Henrique da Costa Avelar, Sophia Tsoka, Lars Bullinger, Elisa Seubert, Daniel J Smit, Carsten Bokemeyer, Christin Ackermann, Jasmin Wellbrock, Friedrich Haag, Walter Fiedler

Journal for ImmunoTherapy of Cancer Dec 2022, 10 (12) e004794; DOI: 10.1136/jitc-2022-004794
Long-term outcomes with nivolumab plus ipilimumab versus sunitinib in first-line treatment of patients with advanced sarcomatoid renal cell carcinoma
Brian I Rini, Sabina Signoretti, Toni K Choueiri, David F McDermott, Robert J Motzer, Saby George, Thomas Powles, Frede Donskov, Scott S Tykodi, Sumanta K Pal, Saurabh Gupta, Chung-Wei Lee, Ruiyun Jiang, Nizar M Tannir

Journal for ImmunoTherapy of Cancer Dec 2022, 10 (12) e005445; DOI: 10.1136/jitc-2022-005445

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