Clinical/Translational Cancer Immunotherapy

Spatial profiling reveals association between WNT pathway activation and T-cell exclusion in acquired resistance of synovial sarcoma to NY-ESO-1 transgenic T-cell therapy
Katie M Campbell, Maneesha Thaker, Egmidio Medina, Anusha Kalbasi, Arun Singh, Antoni Ribas, Theodore Scott Nowicki

Journal for ImmunoTherapy of Cancer Mar 2022, 10 (3) e004190; DOI: 10.1136/jitc-2021-004190
1α,25(OH)₂D₃ reverses exhaustion and enhances antitumor immunity of human cytotoxic T cells
Peng Li, Xinhai Zhu, Guangchao Cao, Ruan Wu, Ke Li, Wenhui Yuan, Biyun Chen, Guodong Sun, Xichun Xia, Hua Zhang, Xiao Wang, Zhinan Yin, Ligong Lu, Yunfei Gao

Journal for ImmunoTherapy of Cancer Mar 2022, 10 (3) e003477; DOI: 10.1136/jitc-2021-003477
Efficacy of anti-PD-1 and ipilimumab alone or in combination in acral melanoma
Prachi Bhave, Tasnia Ahmed, Serigne N Lo, Alexander Shoushtari, Anne Zaremba, Judith M Versluis, Joanna Mangana, Michael Weichenthal, Lu Si, Thierry Lesimple, Caroline Robert, Claudia Trojanello, Alexandre Wicky, Richard Heywood, Lena Tran, Kathleen Batty, Florentia Dimitriou, Anna Stansfeld, Clara Allayous, Julia K Schwarze, Meghan J Mooradian, Oliver Klein, Inderjit Mehmi, Rachel Roberts-Thomson, Andrea Maurichi, Hui-Ling Yeoh, Adnan Khattak, Lisa Zimmer, Christian U Blank, Egle Ramelyte, Katharina C Kähler, Severine Roy, Paolo A Ascierto, Olivier Michielin, Paul C Lorigan, Douglas B Johnson, Ruth Plummer, Celeste Lebbe, Bart Neyns, Ryan Sullivan, Omid Hamid, Mario Santinami, Grant A McArthur, Andrew M Haydon, Georgina V Long, Alexander M Menzies, Matteo S Carlino

Journal for ImmunoTherapy of Cancer Jul 2022, 10 (7) e004668; DOI: 10.1136/jitc-2022-004668
Platelets subvert antitumor efficacy of T cell-recruiting bispecific antibodies
Martina Svenja Lutz, Boris Klimovich, Stefanie Maurer, Jonas S Heitmann, Melanie Märklin, Latifa Zekri, Gundram Jung, Helmut R Salih, Clemens Hinterleitner

Journal for ImmunoTherapy of Cancer Feb 2022, 10 (2) e003655; DOI: 10.1136/jitc-2021-003655
IOLite: phase 1b trial of doublet/triplet combinations of dostarlimab with niraparib, carboplatin–paclitaxel, with or without bevacizumab in patients with advanced cancer
Timothy A Yap, Alberto Bessudo, Erika Hamilton, Jasgit Sachdev, Manish R Patel, Jordi Rodon, Lena Evilevitch, Meghan Duncan, Wei Guo, Sujatha Kumar, Sharon Lu, Bruce J Dezube, Nashat Gabrail

Journal for ImmunoTherapy of Cancer Mar 2022, 10 (3) e003924; DOI: 10.1136/jitc-2021-003924
Quantitative tissue analysis and role of myeloid cells in non-small cell lung cancer
Brian S Henick, Franz Villarroel-Espindola, Ila Datar, Miguel F Sanmamed, Jovian Yu, Shruti Desai, Alice Li, Adam Aguirre-Ducler, Konstantinos Syrigos, David L Rimm, Lieping Chen, Roy S Herbst, Kurt A Schalper

Journal for ImmunoTherapy of Cancer Jul 2022, 10 (7) e005025; DOI: 10.1136/jitc-2022-005025
Intratumoral IL-1R1 expression delineates a distinctive molecular subset with therapeutic resistance in patients with gastric cancer
Puran Zhang, Yun Gu, Hanji Fang, Yifan Cao, Jieti Wang, Hao Liu, Heng Zhang, He Li, Hongyong He, Ruochen Li, Chao Lin, Jiejie Xu

Journal for ImmunoTherapy of Cancer Feb 2022, 10 (2) e004047; DOI: 10.1136/jitc-2021-004047
Efficacy and safety of anti-PD1 monotherapy or in combination with ipilimumab after BRAF/MEK inhibitors in patients with BRAF mutant metastatic melanoma
Ines Pires da Silva, Danny Zakria, Tasnia Ahmed, Claudia Trojanello, Florentia Dimitriou, Clara Allayous, Camille Gerard, Lisa Zimmer, Serigne Lo, Olivier Michielin, Celeste Lebbe, Johanna Mangana, Paolo Antonio Ascierto, Douglas B Johnson, Matteo Carlino, Alexander Menzies, Georgina Long

Journal for ImmunoTherapy of Cancer Jul 2022, 10 (7) e004610; DOI: 10.1136/jitc-2022-004610
CircITGB6 promotes ovarian cancer cisplatin resistance by resetting tumor-associated macrophage polarization toward the M2 phenotype
Han Li, Fan Luo, Xingyu Jiang, Weijing Zhang, Tong Xiang, Qiuzhong Pan, Liming Cai, Jingjing Zhao, Desheng Weng, Yue Li, Yuhu Dai, Fengze Sun, Chaopin Yang, Yue Huang, Jieying Yang, Yan Tang, Yulong Han, Mian He, Yanna Zhang, Libing Song, Jian-Chuan Xia

Journal for ImmunoTherapy of Cancer Mar 2022, 10 (3) e004029; DOI: 10.1136/jitc-2021-004029
Mortality after acute kidney injury and acute interstitial nephritis in patients prescribed immune checkpoint inhibitor therapy
Megan L Baker, Yu Yamamoto, Mark A Perazella, Nazli Dizman, Anushree C Shirali, Navid Hafez, Jason Weinstein, Michael Simonov, Jeffrey M Testani, Harriet M Kluger, Lloyd G Cantley, Chirag R Parikh, F Perry Wilson, Dennis G Moledina

Journal for ImmunoTherapy of Cancer Mar 2022, 10 (3) e004421; DOI: 10.1136/jitc-2021-004421

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